DIRECT GYNAECOGENIC AND INDIRECT OESTROGENIC ACTION OF TESTOSTERONE PROPIONATE IN FEMALE RATS

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Abstract
The numerous publications on the action of androgens on the female animal have shown that quite different types of effects may be produced by closely related substances of the male sex-hormone group. In some cases, however, the type of response has been found to vary with the substance under different experimental conditions. These findings would suggest that some of the effects ascribed to the various androgens may in reality be the resultant of a direct action and an indirect one through interaction with other hormones. In the following observations an attempt has been made to investigate fully the action of testosterone propionate in the female rat. The changes produced in ovariectomized adult rats have been compared with those after hypophysectomy, and the response of the immature hypophysectomized rat has been determined before and after ovarian stimulation by gonadotrophic hormones. As will be shown, testosterone propionate may under some conditions produce

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