Inhibition by Low Molecular Weight Dextran of the Blood Pressure Fall and the Lowering of Plasminogen Proactivator Induced by Clinical Dextran in the Rat

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Abstract
The i.v. injection into rats of dextran with a MW of 1000 (LMr dextran) in doses .gtoreq. 200 mg/kg induced rapid, but transient falls in blood pressure. Pretreatment of the rats with LMr dextran 200 mg/kg caused a partial inhibition of the profound blood pressure fall induced by the injection of clinical dextran with a MW of 70,000 (HMr dextran), 40 mg/kg. In accordance with previous works the i.v. injection of HMr dextran lowered the plasma levels of plasminogen proactivator (pro-PGA) and functionally active high molecular wt kininogen (HMrK). Also LMr dextran, 200 mg/kg, induced significant reductions in the mentioned parameters, but less extensive than those obtained by HMr dextran, 40 mg/kg, and pretreatment of the rats with LMr dextran inhibited the subsequent effects of HMr dextran. A dextran-activated plasminogen activator may be an early link in the mechanism underlying the dextran-induced state of anaphylactoid shock in the rat.

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