Antimalarial activity of cyclosporin A

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Abstract
Cyclosporin A has been shown to possess antimalarial activity in mice infected withPlasmodium berghei NK 65 orPlasmodium chabaudi. Significant antimalarial effects were obtained with five daily oral doses of 25 mg/kg. Cyclosporin A treatment started concurrently with the inoculation of parasites was less effective than treatment started when parasitaemia was already established. Evidence so far suggests that the antimalarial action results from a direct toxic effect on the parasite. Combined treatment with Cyclosporin A and Pyrimethamine indicated that the two compounds may act synergistically.