Treatment of Recurrent Calcium Stone Formation with Cellulose Phosphate

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Abstract
Sodium cellulose phosphate was given to 35 patients for recurrent formation of Ca-containing stones. During therapy, urinary Ca decreased by 40% in the 1st mo. and remained at this lower level. Urinary Mg excretion was reduced and the urinary Mg/Ca ratio remained unaffected. In these patients, who mostly had had calcium oxalate stones, the prophylactic effects of sodium cellulose phosphate was poor, with a 47% recurrence rate after 2 years. This lack of prevention, despite the significant reduction of the urinary Ca, is assumed to be owing to the effects of treatment on Mg and oxalate metabolism. Side effects were common, mainly consisting of moderate gastrointestinal discomfort and caused withdrawal of treatment in 8 patients. Sodium cellulose phosphate is not the drug of choice in cases of calcium oxalate stone formation.