Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems
- 8 April 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 240 (4849) , 219-221
- https://doi.org/10.1126/science.2832949
Abstract
Specific σ binding sites have been identified in the mammalian brain and lymphoid tissue. In this study, certain gonadal and adrenal steroids, particularly progesterone, were found to inhibit σ receptor binding in homogenates of brain and spleen. The findings suggest that steroids are naturally occurring ligands for σ receptors and raise the possibility that these sites mediate some aspects of steroid-induced mental disturbances and alterations in immune functions.This publication has 33 references indexed in Scilit:
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