A Mass Spectrometric Method for Use of Stable Isotopes as Tracers in Studies of Iron, Zinc, and Copper Absorption in Human Subjects
- 1 July 1982
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 112 (7) , 1414-1424
- https://doi.org/10.1093/jn/112.7.1414
Abstract
Stable isotopes of iron, zinc, and copper can be used singly and in combination as tracers of mineral metabolism in human subjects. A mass spectrometric method of analysis that uses chelation of these metals with tetraphenylporphyrin was developed. Absorption can be determined by measuring isotope appearance in feces after a single pulse dose. The method is satisfactory for 54Fe, 67Zn, and 65Cu. Detection of 57Fe and 70Zn in feces is not very reliable.Keywords
This publication has 30 references indexed in Scilit:
- Volatile complexes for the determination of calcium in blood plasma by isotope dilution mass spectrometryJournal of Mass Spectrometry, 1980
- Isotope ratio measurements of urinary calcium with a thermal ionization probe in a quadrupole mass spectrometerAnalytical Chemistry, 1980
- High precision isotopic ratio analysis of volatile metal chelatesAnalytical Chemistry, 1980
- Mass spectrometry of a volatile Mg chelate in the measurement of stable 26Mg when used as a tracerClinica Chimica Acta; International Journal of Clinical Chemistry, 1979
- Ultratrace metals in some environmental and biological systemsAnalytical Chemistry, 1976
- Radioisotope Dilution Technique for Determination of Zinc Absorption in vivoAnnals of Nutrition and Metabolism, 1976
- Charge localization and aromatic stabilization in large ring ions: Mass spectra of ms-porphyrinsJournal of Mass Spectrometry, 1974
- Lead Metabolism in the Normal Human: Stable Isotope StudiesScience, 1973
- Electron‐impact studies of ms‐porphyrinsJournal of Mass Spectrometry, 1970
- Anion Exchange Studies. VI.1,2 The Divalent Transition Elements Manganese to Zinc in Hydrochloric AcidJournal of the American Chemical Society, 1953