OTIC COMPLICATIONS OF STREPTOMYCIN THERAPY
- 11 January 1947
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 133 (2) , 87-91
- https://doi.org/10.1001/jama.1947.02880020013004
Abstract
Neurotoxic symptoms involving the vestibular and auditory systems may occur following streptomycin therapy. Hinshaw and Feldman1 mentioned 1 case of transient deafness and 3 cases of apparent disturbances of vestibular function when large doses of streptomycin were administered over long periods of time. Molitor and his co-workers2 found signs of pronounced disturbances of vestibular function in dogs after extremely large doses of the drug (ten to twenty times the usual human dose per kilogram of body weight). Mushett and Martland3 did not observe pathologic changes in the central nervous systems of these dogs. The first specialized report of aural complications in human beings has been made by Brown and Hinshaw.4 Our series of 81 cases from a large military hospital consists of patients who received streptomycin during the period November 1945 to August 1946. During this same period approximately 80 other patients received the drug inKeywords
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