The synthesis of homoproaporphine-type compounds by phenolic oxidative coupling
- 1 January 1968
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 271-275
- https://doi.org/10.1039/j39680000271
Abstract
Oxidation of 1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxyphenethyl)-6-methoxy-2-methylisoquinoline (III) with potassium ferricyanide or ferric chloride afforded a homoproaporphine (XIII) in good yield by coupling the 8-position of the isoquinoline to the 1-position of the phenethyl group. The syntheses of (III) and its 1-(3-hydroxy-4,5-dimethoxyphenethyl) analogue (IV) are also described.Keywords
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