CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (12) , 1211-1217
- https://doi.org/10.7164/antibiotics.31.1211
Abstract
A new antitumor antibiotic is produced in fermentation liquors of Streptomyces zelensis sp. nov. The antibiotic is biologically active at extremely low concentrations. At 40 pg/ml, it inhibited 90% of the growth of [mouse leukemia] L1210 cells in culture in tube dilution assays. The minimal inhibitory concentrations against gram-positive bacteria is 1-10 ng/ml, while these values for gram-negative bacteria and fungi are mostly under 1 .mu.g/ml. A microbiological assay with Bacillus subtilis can detect concentrations of 1-2 ng/ml.This publication has 3 references indexed in Scilit:
- Streptomyces steffisburgensis sp.nJournal of Bacteriology, 1967
- Zur Systematik der ActinomycetenArchiv für Mikrobiologie, 1958
- The Utilization of Carbon Compounds by Some Actinomycetales as an Aid for Species DeterminationJournal of Bacteriology, 1948