Chemical Strategies for Activity‐Based Proteomics
- 19 December 2003
- journal article
- review article
- Published by Wiley in ChemBioChem
- Vol. 5 (1) , 41-47
- https://doi.org/10.1002/cbic.200300721
Abstract
The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small‐molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity‐based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.Keywords
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