Effect of lipophilicity of trichosporin-Bs on ion-channel formation and catecholamine-releasing activity.
- 1 January 1995
- journal article
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 18 (4) , 640-642
- https://doi.org/10.1248/bpb.18.640
Abstract
A series of peptaibols, trichosporin (TS) -Bs, induced voltage-activated conductance in lipid bilayer membranes and catecholamine secretion from bovine adrenal chromaffin cells. The order of activities is the same as that of the lipophilicity rank of TS-Bs derived from the reversed-phase HPLC capacity factors.Keywords
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