A Redetermination of the Concentration of α2-Macroglobulin in Human Plasma

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Abstract
The concentration of .alpha.2-macroglobulin in human plasma has been remeasured utilizing a carefully isolated and characterized sample of .alpha.2-macroglobulin as a standard. A highly purified sample of .alpha.2-macroglobulin with a total trypsin binding capacity of 1.7 mol trypsin/mol .alpha.2-macroglobulin was used as a standard for both a radial immunodiffusion and a rocket immunoelectrophoresis technique. With this preparation as a standard, the concentration of .alpha.2-macroglobulin in a normal plasma pool over 10,000 donors was found to be about 1.2 mg/ml. A similar concentration (1.3 mg/ml) was found when using a functional trypsin binding assay. This concentration is considerably less than the usually accepted mean of the normal range for .alpha.2-macroglobulin.

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