Indictment of the microglia as the villain in multiple sclerosis

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Abstract
In contrast to autoantibody-mediated autoimmune disease, evidence for the role of autoreactive T cells in autoimmune disease has been difficult to prove. This is in part because T-cell reactivity to autoantigens is present in the normal healthy population and there is no system to test the pathogenicity of autoreactive T cells. Nonetheless, rheumatoid arthritis, MS, inflammatory bowel disease, and insulin-dependent diabetes mellitus are thought to represent T-cell-mediated autoimmune disease. In this paradigm, the end-organ damage is not the result of antibodies to self-antigens but due in part to a delayed type hypersensitivity, cytokines, and cytotoxic T-cell …