Acid hydrolases in pia‐arachnoid and ependyma of rat brain

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Abstract
Activities of several lysosomal enzymes have been measured by ultramicrochemical methods and found to be 2.5 to 3 times higher in normal rat leptomeninges than in subjacent cerebral cortex layers I and II. When interpreted in conjunction with enzyme histochemical techniques, this high activity may be further localized in leptomeningeal cells and macrophages (including pericytes). Ependyma: tissue was found to possess relatively low activity, on the order of that of layer II. Further evidence in favor of the previously reported existence of multiple molecular forms of acid phosphatase in rat brain has been obtained.