THE METABOLISM AND ELIMINATION OF S-CARBOXYMETHYL-L-CYSTEINE IN MAN

  • 1 January 1982
    • journal article
    • research article
    • Vol. 10  (1) , 61-62
Abstract
[S-Carboxymethyl-L-cysteine [3-(S-carboxymethylthio)alanine] is a mucolytic agent presently being used in Europe as supportive therapy in the treatment of respiratory disorders.] The metabolism of 14C- and 35S-labeled S-carboxymethylcysteine (SCMC) was compared. The majority of the dose appeared in urine in the first 24 h, no activity was detectable in feces. Use of 35S-labeled compound gave small amounts of inorganic 35S-sulfate, whereas 14C-labeled material was degraded to give some [14C]urea. Peak excretion of the parent compound occurred first after administration of SCMC; metabolites requiring 1 chemical modification for their formation were maximally excreted 1-4 h after the dose and those involving more metabolic processes appeared later (4-8 h).

This publication has 1 reference indexed in Scilit: