Sterol composition of itraconazole-resistant and itraconazole-susceptible isolates of Aspergillus fumigatus

1 August 2001

journal article
Published by Canadian Science Publishing in Canadian Journal of Microbiology

Vol. 47 (8) , 706-710
https://doi.org/10.1139/w01-066

Abstract

Sterol composition of four clinical isolates of Aspergillus fumigatus resistant to itraconazole was determined by gas chromatography – mass spectrometry and compared with that of four susceptible strains. For all strains, the major sterol was ergosterol. Sterol compositions were qualitatively and quantitatively similar for the resistant and susceptible strains. These results suggest that itraconazole resistance is not related, for the strains studied, to alterations in the ergosterol synthesis pathway.Key words: Aspergillus fumigatus, itraconazole resistance, sterol composition.

Keywords

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