A Convenient Synthesis of 1-(S)-[1’-(S)-(t-Butyloxycarbonylamino)-2’-phenylethyl]oxirane, a Versatile Intermediate for the Preparation of Hydroxyethylamine Based HIV Protease Inhibitors

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Abstract
A concise, stereocontrolled synthesis of N-protected (1S,1’S)-α-aminoepoxides, important intermediates for the preparation of hydroxyethylamine dipeptide isosteres, beginning with α-aminoesters is described.