Male Germ Cell‐Expressed Mouse Gene TAZ83 Encodes a Putative, Cysteine‐rich Transmembrane Protein (cyritestin) Sharing Homologies with Snake Toxins and Sperm‐Egg Fusion Proteins
- 1 February 1994
- journal article
- Published by Wiley in Development, Growth & Differentiation
- Vol. 36 (1) , 49-58
- https://doi.org/10.1111/j.1440-169x.1994.00049.x
Abstract
Data obtained by cloning of a mouse cDNA (TAZ83) are presented. Its corresponding gene is expressed in meiotic and haploid testicular germ cells. The gene encodes a putative, cysteine-rich transmembrane protein with a deduced molecular weight of 90 kilodaltons and an isoelectric point of 5.4. Cysteine patterns within the predicted amino acid sequence of the TAZ83 gene product (cyritestin, cysteine-rich, testicular) are highly conserved when compared to various snake toxins of the disintegrin metalloproteinase type. The cysteine pattern conservation between cyritestin and a guinea pig sperm-egg fusion protein suggests that TAZ83 codes for a mouse protein with comparable properties or function.Keywords
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