The Use of Cortisone and ACTH in Rheumatoid Disease in Swine

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Abstract
There are disease conditions in swine which resemble rheumatic or rheumatoid diseases in the human. Clinically these conditions are accompanied by skin lesions, lameness, arthritis, and, sometimes, elevated body temp. The pathologic changes in the joints consist mainly of fibrotic periarthritis, hypertrophic synovial villi and deterioration of the articular cartilage and adjacent bone. The gross-visceral lesions consist principally of fibrinous and fibrous changes on the serous surfaces. Carditis is a common microscopic finding. Cortisone, 100 mg. daily, was injd. intramusc. into each of 3 hogs showing marked symptoms of lameness. All showed definite improvement in 3-4 days. Treatment lasted 5-7 days. Symptoms returned in 2 of the animals 2-3 days after treatment was stopped. One animal was then treated with 40 mg. of ACTH intramusc. daily for 5 days without results. The other hog was treated again with cortisone. Definite improvement occurred on the 3d day. Nine days after retreatment was stopped marked symptoms had returned. ACTH was used on another hog showing marked lameness. Definite improvement appeared 3 days later and continued during 6 days of treatment. Symptoms returned 3 days after treatment was stopped.

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