Chlorpromazine treatment of blood-brain barrier dysfunction a quantitative and fluorescence microscopical study on small cerebral stab wounds in the rat

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Abstract
The extravasation of albumin around small cerebral stab wounds in the rat frontal cortex was studied by fluorescence microscopy after i. v. injection of Evans blue-labeled albumin and by quantitative immunoelectrophoresis after i.v. injection of bovine albumin, in both nonintoxicated and ethanolintoxicated rats. The extravasation of albumin was enhanced in ethanol-intoxicated compared to nonintoxicated rats, as studied both by immunoelectrophoresis and by fluorescence microscopy. Administration of chlorpromazine (2 mg/kg body weight i. v.) 16 h after inflicting cerebral stab wounds decreased the area around the wound showing extravasation of Evans blue-labeled albumin as studied by fluorescence microscopy both in nonintoxicated and in ethanol-intoxicated rats. Quantitative studies showed a significant decrease in the amount of extravasated albumin around cerebral stab wounds in ethanol-entoxicated rats, while the extravasation in nonintoxicated rats was not significantly changed by chlorpromazine treatment.