Transmission of reflexes arising on both sides of the gastroduodenal junction

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Abstract
Reflex phenomena arising on both sides of the gastroduodenal junction have been studied in anesthetized dogs. Electrical and mechanical activity was usually recorded simultaneously from both sides. The correlation between electrical and mechanical activity has been cited. Gastric distention has a reflex inhibitory effect on the electrical and mechanical activity of the duodenum. This response was blocked by reserpine and guanethidine. In reserpine-treated animals responses were temporarily restored by norepinephrine injection. Bilateral vagotomy and pyloric section did not abolish this response. Duodenal distention or marked contractions caused temporary slowing of the antral rhythm and a corresponding reduction in frequency of peristaltic contractions. This response was abolished by chemical sympathectomy and bilateral vagotomy. Pyloric section was not sufficient to block this response in all animals.