Chromosomal anomalies in patients with retinoblastoma
- 1 July 1977
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 12 (1) , 1-8
- https://doi.org/10.1111/j.1399-0004.1977.tb00894.x
Abstract
Karyotypes from 50 persons with retinoblastoma confirmed by histopathological examination were studied by conventional staining and Giemsa-banding techniques. Two chromosomal anomalies were found. An interstitial deletion of the long arm of no. 13 chromosome was identified by Giemsa-banding in the karyotypes from a boy with unilateral retinoblastoma. Another boy with unilateral tumor had a karyotype of 47, XXY. A deletion of chromosome no. 13, most likely involving band 13q14, is associated with the development of retinoblastoma. Retinoblastoma may be found more frequently in children with chromosomal aneuploidy.This publication has 24 references indexed in Scilit:
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