High Performance Liquid Chromatography of New Potential Anxiolytic Drugs and Related Benzodiazepines: A Comparative Study of Hydrophobicity

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Abstract
A comparative study of hydrophobicity in diazepam (5) chlordizepoxide (6), buspirone (7) and four related pyrrolothieno-1,4-dizepine systems (1–4) has been carried out, using HPLC (RPC) technique. The capacity factors (K') of compounds studied have been measured in five different elution conditions (mobile phase in which the percentage of methanol varies). The capacity factors (K'0) corresponding to the absence of organic solvent in the mobile phase have been calculated. Correlations among hydrophobic parameters of series 1, 2, 3, and 4 have been established and K'0 of compounds not yet synthesized have been calculated.