Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates

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Abstract
Tolerance and cross tolerance to the antinociceptive effect of equipotent doses of morphine (10 μg/kg) and mescaline (100 μg/kg) are shown in the rabbit after their repeated intracerebroventricular administration. The recording of the electrical activity of different brain areas indicates that a partial tolerance also develops to the EEG effects in animals undergoing chronic treatment with mescaline. The comparison of certain of the mescaline-induced effects with those of morphine suggests that some biochemical and neural patterns are common to the 2 drugs.