Protein lysine methyltransferase G9a acts on non-histone targets
- 27 April 2008
- journal article
- research article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 4 (6) , 344-346
- https://doi.org/10.1038/nchembio.88
Abstract
By methylation of peptide arrays, we determined the specificity profile of the protein methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is inhibited by methylation of the arginine residue. Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB. We demonstrate potential downstream signaling pathways for methylation of non-histone proteins.Keywords
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