Studies on Amine Oxidase: Effects of Chlorpromazine and its Analogues

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Abstract
Serotonin, noradrenaline and histamine are thought to play an important role in the nervous system (2,2). The physiological role of amine oxidase, which catalyzes the oxidative deamination of such biologically active amines, has been the subject of controversy (3,4), and various inhibitors have been used for the study of this enzyme. In previous studies (5,6) it was shown that chlorpromazine inhibits the oxidative deamination of serotonin both in vivo and in vitro. Many papers have recently appeared with respect to the biochemical actions of this new psychotherapeutic drug (7) and evidence has been accumulated showing that it strongly inhibits various enzymes and enzyme systems. However the mechanism of this inhibition is still unknown. It seemed therefore to be of interest to know the mechanism of inhibition of amine oxidase by chlorpromazine. This paper presents the results of the inhibitory effect of chlorpromazine on monoamine oxidase and of the effect of sulfhydryl compounds and FAD on the inhibition of the enzyme by chlorpromazine in vitro. Studies have also been made on the effect on monoamine oxidase of various compounds structually related to chrorpromazine and on the effect of chlorpromazine on monoamine oxidase in vivo.