Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202
- 21 January 1999
- journal article
- Published by Springer Nature in Oncogene
- Vol. 18 (3) , 807-811
- https://doi.org/10.1038/sj.onc.1202369
Abstract
Interferons (IFNs) can exert cytostatic and immunomodulatory effects on carcinoma cells. In particular, growth inhibition of human prostate carcinoma by IFNs has been demonstrated both in vitro and in vivo. p202 is a 52 kd nuclear phosphoprotein known to be induced by IFNs. In this report, we showed that the expression of p202 was associated with an anti-proliferative effect on human prostate cancer cells. More importantly, cells that expressed p202 showed reduced ability to grow in soft-agar, indicating a loss of transformation phenotype. Our data suggest that p202 is a growth inhibitor gene in prostate cancer cells and its expression may also suppress transformation phenotype of prostate cancer cells.Keywords
This publication has 21 references indexed in Scilit:
- Increase in p202 Expression during Skeletal Muscle Differentiation: Inhibition of MyoD Protein Expression and Activity by p202Molecular and Cellular Biology, 1998
- Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanomaOncogene, 1997
- Inhibition of E2F-4/DP-1-stimulated transcription by p202Oncogene, 1997
- p202, an Interferon-inducible Modulator of Transcription, Inhibits Transcriptional Activation by the p53 Tumor Suppressor Protein, and a Segment from the p53-binding Protein 1 That Binds to p202 Overcomes This InhibitionPublished by Elsevier ,1996
- The Interferon-Inducible Growth-Inhibitory p202 Protein: DNA Binding Properties and Identification of a DNA Binding DomainBiochemical and Biophysical Research Communications, 1996
- Binding of an Interferon-inducible Protein (p202) to the Retinoblastoma ProteinPublished by Elsevier ,1995
- Interferon Action: Cytoplasmic and Nuclear Localization of the Interferon-Inducible 52-kD Protein That Is Encoded by the Ifi 202 Gene from the Gene 200 ClusterJournal of Interferon Research, 1993
- References for Pierce from page 15Inquiry: Critical Thinking Across the Disciplines, 1993
- INTERFERONSThe Lancet, 1989
- COMBINATION OF RECOMBINANT INTERFERONS ALPHA AND GAMMA IN TREATMENT OF CHRONIC HEPATITIS BThe Lancet, 1987