Dopamine and Saralasin Antagonism of Renal Vasoconstriction and Oliguria Caused by Amphotericin B in Dogs

Publisher Website
Google Scholar
Abstract
Amphotericin B (2.5 mg/kg, administered i.v.) increased vascular resistance (renal more than pulmonary more than systemic) and decreased glomerular filtration and urine flow 94% in 16 anesthetized female mongrel dogs. Dopamine decreased renal vascular resistance 31% in 14 dogs; when amphotericin B was given with dopamine, there was partial antagonism of amphotericin B-induced renal vasoconstriction. Saralasin partially antagonized amphotericin B-induced renal vasoconstriction in 7 dogs. When amphotericin B was given during combined infusion of dopamine and saralasin in 8 dogs, renal blood flow remained at initial control levels, urine flow increased above initial levels and glomerular filtration decreased only 21% from initial values. Amphotericin B increased renal vascular resistance 296% when given alone but only 41% in dogs during injection of dopamine and saralasin (P = 0.002). The antagonism of amphotericin B-induced renal effects by the combination of dopamine and saralasin was significant and specific for the renal vascular bed.