Home treatment of febrile neutropenia: An empirical oral antibiotic regimen

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Abstract
Between May 1988 and November 1989, 68 consecutive febrile courses supervening after polychemotherapy for lymphoma outpatients (median age 50 years) were treated by the combination of oral Pefioxacin/Amoxicillin Clavulanic acid. In terms of median data, neutropenia appeared on d9 [d1–d17], and lasted 5 days [2–9] with a PMN nadir observed at 0.104×109 [0–0.5×109/1], while fever rose on d1O [1–24]. In 59 cases (87%), fever and/or focal symptoms disappeared within 3 days, after which treatment was maintained for 7 days. Nine failures were observed, of which 2 were due to abandonment of treatment, 2 to vomiting and 5 to persistence of the original symptoms. Meti Susceptible-Staphylocci were found in blood samples from 2 patients, one of whom, with grade IV lymphoma that had proved resistant to chemotherapy, died. The treatment was found to be effective and well tolerated, offering a good alternative to hospitalization during a transient chemotherapy-induced neutropenia.

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