ACUTE MYOCARDIAL-INFARCTION IMAGED WITH STANNOUS-TC-99M PYROPHOSPHATE AND TI-201 - CLINICAL EVALUATION

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 17  (9) , 771-779
Abstract
Patients (26) suspected of having acute myocardial infarction (AMI) underwent myocardial scintigraphy sequentially with 201Tl and 99mTc-stannous pyrophosphate (99mTc-PPi). Of the 26 patients, 24 had AMI documented by enzyme and electrocardiographic changes. Nineteen had transmural and 5 had subendocardial myocardial infarctions. The remaining 2 patients had unstable angina pectoris. The mean time from onset to imaging was 4 days. Of the 24 patients with AMI, 22 had positive 99mTc-PPi scintigrams. In 20 the area of acute myocardial damage appeared to be the same by 99mTc-PPi scintigram as by ECG; in 2, the location could not be precisely determined. The 2 major patients with negative 99mTc-PPi scintigrams at the time of combined myocardial imaging previously had positive 99mTc-PPi images. In all 24 patients, the 201Tl images were abnormal in at least the location suggested by the ECG. In 7 patients, the area of decreased 201Tl activity was grossly equal to the positive area on the 99mTc-PPi images; in 15, the 201Tl defect was definitely larger; and in 2, the 201Tl defect appeared slightly smaller. Although the 99mTc-PPi and 201Tl myocardial images provide different information, both are valuable in determining the overall integrity of the myocardium in patients with ischemic heart disease.

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