The effect of acute inflammation on iron metabolism in rats.
- 1 January 1983
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 139 (3) , 293-298
- https://doi.org/10.1620/tjem.139.293
Abstract
Fe metabolism in rats with acute turpentine-induced inflammation was evaluated. In acute inflammation, reduced plasma Fe and total Fe-binding capacity values, shortened plasma Fe disappearance time and lower plasma Fe turnover were observed. Administration of 59Fe chondroitin ferrous sulfate to evaluate RES function revealed a significantly increased 59Fe retention in the liver and lower incorporation into red blood cells. Radioactivity in hepatic RE cells was higher in acute inflammation than in control. A block in the transfer of Fe from RES cells to the plasma Fe pool may occur during acute inflammation.This publication has 0 references indexed in Scilit: