Immunotherapy coming of age: What will it take to make it standard of care for glioblastoma?
Open Access
- 10 December 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in Neuro-Oncology
- Vol. 13 (1) , 3-13
- https://doi.org/10.1093/neuonc/noq169
Abstract
With the recent approval by the FDA of an immunotherapy for prostate cancer and another positive immunotherapy trial in melanoma, immunotherapy may finally be coming of age. So what will it take for it to become part of the standard treatment for glioblastoma? To put this question into perspective, we summarize critical background information in neuro-immunology, address immunotherapy clinical trial design, and discuss a number of extrinsic factors that will impact the development of immunotherapy in neuro-oncology.Keywords
This publication has 134 references indexed in Scilit:
- Improved Survival with Ipilimumab in Patients with Metastatic MelanomaNew England Journal of Medicine, 2010
- Glioma cancer stem cells induce immunosuppressive macrophages/microgliaNeuro-Oncology, 2010
- Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activationHuman Immunology, 2009
- Clinical benefit in Phase-I trials of novel molecularly targeted agents: does dose matter?British Journal of Cancer, 2009
- Self-antigen–specific CD8+ T cell precursor frequency determines the quality of the antitumor immune responseThe Journal of Experimental Medicine, 2009
- CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefitProceedings of the National Academy of Sciences, 2008
- Postoperative Adjuvant Dendritic Cell–Based Immunotherapy in Patients with Relapsed Glioblastoma MultiformeClinical Cancer Research, 2008
- Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza VaccinesJournal of Virology, 2006
- Radiotherapy plus Concomitant and Adjuvant Temozolomide for GlioblastomaNew England Journal of Medicine, 2005
- Tumour-educated macrophages promote tumour progression and metastasisNature Reviews Cancer, 2004