Inorganic Fluoride Nephrotoxicity
Open Access
- 1 April 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 46 (4) , 265-271
- https://doi.org/10.1097/00000542-197704000-00007
Abstract
The effects of prolonged enflurane and halothane administration on urine-concentrating ability were determined in volunteers by examining their responses to vasopressin before anesthesia and on days 1 and 5 after anesthesia. A significant decrease in maximum urinary osmolality of 264 .+-. 34 mOsmol/kg (26% of the preanesthetic value) was present on day 1 after enflurane anesthesia, whereas subjects anesthetized with halothane had a significant increase in maximum urinary osmolality of 120 .+-. 44 mOsm/kg. Serum inorganic fluoride level peaked at 33.6 .mu.M and remained above 20 .mu.M for approximately 18 h. The threshold level for inorganic fluoride nephrotoxicity was lower than previously suspected.This publication has 0 references indexed in Scilit: