Crystal structure of leucine-enkephalin
- 1 December 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 306 (5942) , 447-450
- https://doi.org/10.1038/306447a0
Abstract
The crystal structure of leucine-enkephalin has been determined in a crystal form that has four independent enkephalin molecules and much water and dimethylformamide solvent in the asymmetric unit. All four enkephalins have extended peptide backbones with the Tyr, Phe and Leu side chains above and below the plane of the backbone. There is evidence that this extended conformation may provide an acceptably model for enkephalin binding to opiate μ-receptors.Keywords
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