The Effect of Hypophysectomy upon the metabolism of Grafted Tumor Tissue

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Abstract
Numerous attempts have been made to establish a relationship between the pituitary gland and tumor growth. Zondek and his co-workers (1) and Cannavo (2) concluded from their experimental work that the growth of grafted tumors could be inhibited or retarded by injections of prolan. This could not be confirmed by Krehbiel, Haagensen, and Plantenga (3), nor by Suginra and Benedict (4), nor by Wiesner and Haddow (5). Gross (6), on the other hand, observed slightly accelerated growth in mouse sarcoma when using comparatively small doses of prolan; and Bischoff and his co-workers (7) found that standardized growth-promoting preparations of the pituitary significantly accelerated the ratc of growth of carcinoma 256 in older rats. Bischoff and his associates (7) also found that pituitary irradiation retarded the growth rate of grafted tumors in rats and mice. Ball, Samuels, and Simpson (8, 9) reported a smaller percentage of takes and a retardation of growth of the Walker transplantable mammary carcinoma in hypophysectomized rats. McEuen and Thomson (10) found that hypophysectomy retarded but did not prevent the growth of the Walker rat tumor, and also found that semi-starvation, similar to that which obtains in hypophysectomized rats, resulted in a retardation of tumor growth equivalent to that produced by hypophysectomy.

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