Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells: Synergy with parathyroid hormone
- 1 November 1988
- journal article
- research article
- Published by Springer Nature in Calcified Tissue International
- Vol. 42 (6) , 358-362
- https://doi.org/10.1007/bf02556353
Abstract
Summary Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E2 (PGE2) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 hour) and the potency of IL-1 (5×10−12 M) in producing this effect suggest that IL-1 may exert some of its effects on bone via PGE2. Parathyroid hormone (PTH) appears to have a strong synergistic effect with IL-1. These data further substantiate the role of IL-1 in bone physiology.Keywords
This publication has 30 references indexed in Scilit:
- Recombinant human interleukin 1 alpha and beta stimulate mouse osteoblast-like cells (MC3T3-E1) to produce macrophage-colony stimulating activity and prostaglandin E2Biochemical and Biophysical Research Communications, 1986
- Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.The Journal of Experimental Medicine, 1986
- Stimulation of prostaglandin E2 and bone resorption by recombinant human interleukin 1 alpha in fetal mouse bonesBiochemical and Biophysical Research Communications, 1986
- Clonal differences in prostaglandin synthesis among osteosarcoma cell linesJournal of Bone and Mineral Research, 1986
- There is more than one interleukin 1Immunology Today, 1986
- Cloning and expression of murine interleukin-1 cDNA in Escherichia coliNature, 1984
- Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitroBiochimica et Biophysica Acta (BBA) - General Subjects, 1984
- Interleukin 2‐independent stimulation of rabbit chondrocyte collagenase and prostaglandin E2 production by an interleukin 1‐like factorEuropean Journal of Immunology, 1984
- Interleukin-1Clinical Infectious Diseases, 1984
- An interleukin 1 like factor stimulates bone resorption in vitroNature, 1983