Dermatomyositis With Cerebral Vasculitis in a Patient With Agammaglobulinemia

1 January 1972

journal article
research article
Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine

Vol. 123 (1) , 53-56
https://doi.org/10.1001/archpedi.1972.02110070103015

Abstract

This paper describes a case of dermatomyositis occurring in a patient with agammaglobulinemia. A major manifestation of the disease process was subarachnoid hemorrhage, presumably due to central nervous system vasculitis. Typical changes of dermatomyositis were found in the skin, muscle, gastrointestinal tract, endocardium, epididymis, and brain. No immunoglobulins or β₁ C-globulin were localized in the sections of skin or muscle. The failure of the patient's peripheral blood lymphocytes to respond to specific antigens in vitro suggests a qualitative disorder of cell-mediated immunity which may have predisposed to the development of dermatomyositis.

Keywords

This publication has 3 references indexed in Scilit:

Involvement of the Central Nervous System in Collagen Disease : Cerebrovascular Disturbance in the Young Subject
Japanese Circulation Journal, 1966
DERMATOMYOSITIS (SYSTEMIC ANGIOPATHY) OF CHILDHOOD
Medicine, 1966
Collagen Diseases and the Nervous System
Medical Clinics of North America, 1963