Methsuximide in Psychomotor and Petit-Mal Seizures
- 1 May 1958
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 258 (18) , 892-894
- https://doi.org/10.1056/nejm195805012581807
Abstract
METHSUXIMIDE (N-methyl-a,a-methylphenylsuccinimide, PM-396) has emerged from studies of many succinimide analogues as an effective antiseizure medication. Use of a related drug, methylphenylsuccinimide, was described by Zimmerman1 in 1951, and reports from a number of clinics followed, two of these2 , 3 from the Seizure Unit. Zimmerman4 , 5 investigated other succinimide preparations. In 1954 he reported that methsuximide (methylphenylsuccinimide) was effective both in petit-mal6 and psychomotor epilepsy,7 and recently8 he obtained "practical to complete" control in 44 to 50 per cent of 100 petit-mal cases refractory to other drugs. Of 35 patients with psychomotor seizures, he now reports that 37 per cent show "practical . . .Keywords
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