γ-GLUTAMYL CYCLOTRANSFERASE: A NEW GENETIC POLYMORPHISM IN THE MOUSE (MUS MUSCULUS) LINKED TO LYT—2
- 1 September 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 99 (1) , 109-116
- https://doi.org/10.1093/genetics/99.1.109
Abstract
Electrophoretically variant forms of γ-glutamyl cyclotransferase have been identified in red cells of inbred mouse strains. Each inbred strain exhibited a major band of activity and a minor band that migrated more anodally. The polymorphism affects the migration of both the major and minor bands in a similar way. F1 hybrids between strains with fast forms (A/J) and strains with the slow forms (C57BL/6J) exhibited a four-banded pattern consistent with co-dominant inheritance. The patterns observed in backcross and F2 mice were consistent with the segregation of a pair of autosomal co-dominant alleles. Recombinant inbred strains and a congenic strain were used to show that the locus controlling γ-glutamyl cyclotransferase (Ggc) is linked to Lyt-2, a lymphocyte alloantigen locus on chromosome 6, with an estimated map distance of 5.0 ± 2.5 centimorgans.Keywords
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