Effects of β-Adrenergic Blockade on Endurance and Short-Time Performance in Respect to Individual Muscle Fiber Composition*
- 1 February 1981
- journal article
- clinical trial
- Published by Georg Thieme Verlag KG in International Journal of Sports Medicine
- Vol. 02 (01) , 37-42
- https://doi.org/10.1055/s-2008-1034582
Abstract
Nine physically active males were studied three times with four different exercise tests after administration of placebo, 0.1 g atenolol, or 0.08 g propranolol in random order. The test modals were: bicycle ergometer exercise at 50% of V̇O2max, peak torque during knee extension, the Wingate muscle power test, and 2000 m track running. Muscle fiber composition had previously been determined. In subjects with a high percentage of slow-twitch fibers the β-blockers caused a more marked impairment in the exercising muscles. This effect was more pronounced with the unselective β-blocker propranolol than with atenolol. One interpretation of our findings is that peripheral sympathetic β2-receptors in skeletal muscles may contribute to regulating muscle metabolism.Keywords
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