THE EFFECT OF DIURETICS ON THE FAECAL EXCRETION OF WATER AND ELECTROLYTES IN HORSES

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Abstract
1 The effect on plasma, urinary and faecal electrolytes of frusemide and hydrochlorthiazide was measured in ponies, mean weight 180 kg. 2 The rapid loss in urine of large quantities of sodium had only a small effect on plasma sodium concentration. 3 Faecal sodium excretion was increased substantially after the administration of frusemide. 4 Frusemide increased faecal potassium during the 48 h following administration and faecal water in the 24/48 h period. It also produced a hypopotassaemia. 5 Hydrochlorthiazide increased faecal chloride during the 24 h after administration. 6 Frusemide increased the intestinal transit time of both liquid (polyethylene glycol) and particulate (Cr2O3) markers.

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