Helper-Dependent Adenoviral Vectors for Gene Therapy
- 1 January 2005
- journal article
- research article
- Published by Mary Ann Liebert Inc in Human Gene Therapy
- Vol. 16 (1) , 1-16
- https://doi.org/10.1089/hum.2005.16.1
Abstract
Helper-dependent adenoviral vectors possess a number of characteristics that make them attractive gene therapy vectors. These vectors are completely devoid of viral coding sequences and are able to mediate high-efficiency transduction in vivo to direct sustain high-level transgene expression with negligible chronic toxicity. This review focuses on advances in helper-dependent adenoviral vector technology, selected examples of in vivo studies of particular interest, and the issue of vector-mediated acute toxicity.Keywords
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