Synthesis of active forms of vitamin D. Part IX. Synthesis of 1α,24-dihydroxycholecalciferol
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 14,p. 1421-1424
- https://doi.org/10.1039/p19750001421
Abstract
24-Oxocholesterol (1)(readily available from fucosterol) was converted by three steps into 1α,24ξ-dihydroxycholesterol (4). From the corresponding triacetate (5), 1α,24ξ-dihydroxycholecalciferol (9) was prepared via the 5,7-diene (8). The C-24 epimers of compound (4) were resolved by silica gel column chromatography of the monohydroxydibenzoates (7), and were separately transformed into the corresponding 1α,24-dihydroxycholecalciferol epimers.Keywords
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