Chemokine-Induced Secretion of Gelatinase B in Primary Human Monocytes
Open Access
- 30 January 2001
- journal article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 382 (9) , 1405-10
- https://doi.org/10.1515/bc.2001.173
Abstract
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited proteolysis of basement membranes and matrix material. The effect of the chemokines RANTES/CCL5, MCP-1/CCL and SDF-1 /CXCL12 on secretion of the matrix metalloproteinase B and its endogenous inhibitor TIMP-1 was studied. RANTES/CCL5 and SDF-1/CXCL12 were found to induce MMP-9 secretion in primary human monocytes while TIMP-1 secretion was not affected. RANTES/CCL5 effects were mediated through CCR1 because the CCR1 antagonist BX471 was found to effectively block RANTES/CCL5-induced MMP-9 secretion.Keywords
This publication has 24 references indexed in Scilit:
- Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and TH1-like/CD45RO+T cellsBlood, 2001
- A Non-peptide Functional Antagonist of the CCR1 Chemokine Receptor Is Effective in Rat Heart Transplant RejectionPublished by Elsevier ,2001
- Differential MMP and TIMP production by human marrow and peripheral blood CD34+ cells in response to chemokinesExperimental Hematology, 2000
- Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokinesArthritis & Rheumatism, 2000
- Proteolysis and cell migration: creating a path?Published by Elsevier ,1999
- Metalloproteinases and their Tissue Inhibitors in Multiple SclerosisJournal of Autoimmunity, 1999
- On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responsesSeminars in Immunology, 1999
- Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9Annals of Neurology, 1996
- Tumor Cell Interactions with the Extracellular Matrix During Invasion and MetastasisAnnual Review of Cell Biology, 1993
- Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma.Journal of Clinical Investigation, 1990