CALCIUM AND CELL PROLIFERATION

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Abstract
Growth factors and other mitogens stimulate quiescent, non-proliferating cells in cultrue to re-enter the cell cycle and become committed to DNA synthesis in S phase. Most of the biochemical steps that are obligatory for progression to S phase remain to be established, but there are several well-defined responses that occur soon after the additon of mitogens to a variety of cells, including ionic signals, the activation of specific genes and general metabolic stimulation. The earliest of these responses to some, but not all, mitogens are a rise in the free cytosolic Ca 2+ concentration with a coincident release of inositol (1,4,5) trisphosphate. These responses are therefore at least plausible condidates as the initial intracellular activators of the mitogenic pathway. We examine the evidence for this hypothesis in three contrasting types of cell: oocytes, fibroblasts and lymphocytes.

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