The DNA sequence and comparative analysis of human chromosome 10
Open Access
- 1 May 2004
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 429 (6990) , 375-381
- https://doi.org/10.1038/nature02462
Abstract
The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. Sequence annotation revealed 1,357 genes, of which 816 are protein coding, and 430 are pseudogenes. We observed widespread occurrence of overlapping coding genes (either strand) and identified 67 antisense transcripts. Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. Multispecies comparative analysis indicated that we can readily annotate the protein-coding genes with current resources. We estimate that over 95% of all coding exons were identified in this study. Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.Keywords
This publication has 38 references indexed in Scilit:
- The International HapMap ProjectNature, 2003
- GAD2 on Chromosome 10p12 Is a Candidate Gene for Human ObesityPLoS Biology, 2003
- Non–coding RNA genes and the modern RNA worldNature Reviews Genetics, 2001
- A map of human genome sequence variation containing 1.42 million single nucleotide polymorphismsNature, 2001
- Initial sequencing and analysis of the human genomeNature, 2001
- Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10qHuman Molecular Genetics, 2000
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997
- A 9.75-Mb Map across the Centromere of Human Chromosome 10Genomics, 1996
- A Novel Family of Cathepsin L-like (CTSLL) Sequences on Human Chromosome 10q and Related TranscriptsGenomics, 1994
- Three Human Glutamate Dehydrogenase Genes (GLUD1, GLUDP2, and GLUDP3) Are Located on Chromosome 10q, but Are Not Closely Physically LinkedGenomics, 1993