Antifertility action of a sterol sulphate in the rabbit
- 1 September 1982
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 66 (1) , 109-112
- https://doi.org/10.1530/jrf.0.0660109
Abstract
Introduction of 0.5 mg .beta.-sitosteryl sulfate, a potent acrosin inhibitor, in K-Y jelly into the vagina of rabbits before coitus lowered the pregnancy rate [by preventing sperm penetration of the zona pellucida]. Cholesteryl sulfate had no effect. A 1.5 .times. 10 mm silicone rod containing 10% (wt/wt) .beta.-sitosteryl sulfate released 1-2 .mu.g of compound per day over a 16-day period in vitro. When such implants were placed in rabbit uteri, there was a significant reduction in the number of embryos in those horns.This publication has 1 reference indexed in Scilit:
- Acrosin Inhibitors as Vaginal Contraceptives in the Primate and their Acute ToxicityBiology of Reproduction, 1979