Quinacrine in the Treatment of Refractory Petit-Mal Epilepsy

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Abstract
IN 1952 Méndez and Hartley1 reported the disappearance of petit-mal seizures in a seven-year-old boy receiving quinacrine (Atabrine) for a Giardia lamblia intestinal infestation; the petit-mal seizures unexpectedly ceased on the second day after institution of therapy. Since then, several reports from abroad have indicated that quinacrine was effective therapy in a number of children with petit-mal seizures.2 3 4 5 6 7 The appearance of a yellow discoloration of the skin and sclerae after several days of therapy has undoubtedly discouraged more widespread trial of quinacrine in this country. However, it should be emphasized that this cutaneous discoloration is reversible and constitutes an objection . . .

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