Infantile spasms

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Abstract
We have presented a typical case of massive spasms of infancy associated with an electroencephalographic abnormality strongly suggestive of "hypsarhythmia." Pathologic examination of the brain and spinal cord revealed a status fibrosis and cribriform state in the basal nuclei, brain stem, and spinal cord. These changes were associated with profound and advanced cerebellar cortical atrophy. The cerebral cortex and white matter were less affected. Possible causes for the development of gliosis and hypermyelinization of the brain stem and basal nuclei have been discussed. Loss of normal cerebellar function and its relationship to seizure patterns in infancy also have been discussed.

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