Aging and Restriction of Dietary Calories Increases Insulin Receptor mRNA, and Aging Increases Glucocorticoid Receptor MRNA in the Liver of Female C3B10RF1 Mice

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Abstract
We investigated the influence of age and a 20% or 52% reduction in dietary calories (caloric restriction) on expression of mRNA for a number of transcription factors and signal-transducing proteins using4,16, and 30-monthold female mice of the long-lived c3B10RF, strain. In all age groups, 52% caloric restriction, which extends maximum life span by approximately 33%, increased insulin receptor mRNA by 15% to 25% over the levels in animals fed ad libitum. Aging increased insulin receptor mRNA and glucocorticoid receptor mRNA in all dietary groups. A similar increase in glucocorticoid receptor mRNA was not observed for male mice of three other strains, suggesting the change is sex-or strain-specific and not a general feature of aging. These changes appear to be specific. Neither caloric restriction nor age had an effect on the level of mRNA for insulin-like growth factor-I, RNA polymerase II elongation-factor S-II, or transcription factors SPL, CCAAT and enhancer binding protein, or proto-oncogene c-jun.

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